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Comparison between xenogeneic and allogeneic adipose mesenchymal stem cells in the treatment of acute cerebral infarct: proof of concept in rats

机译：异源和异源脂肪间充质干细胞治疗急性脑梗死的比较：概念验证的大鼠

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摘要

BackgroundRat adipose tissue-derived-mesenchymal stem cells (rAD-MSCs) have proven to be safe in experimental animal models of stroke. However, in order to use human AD-MSCs (hAD-MSCs) as a treatment for stroke patients, a proof of concept is needed. We analyzed whether the xenogeneic hAD-MSCs were as safe and effective as allogeneic rAD-MSCs in permanent Middle Cerebral Artery Occlusion (pMCAO) in rats.

机译：背景已证明大鼠脂肪组织间充质干细胞（rAD-MSC）在中风的实验动物模型中是安全的。但是，为了将人AD-MSC（hAD-MSC）用于中风患者的治疗，需要概念证明。我们分析了异源性hAD-MSC在大鼠永久性中脑动脉闭塞（pMCAO）中是否与异基因rAD-MSC一样安全有效。

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期刊名称 Journal of Translational Medicine
作者
María Gutiérrez-Fernández; Berta Rodríguez-Frutos; Jaime Ramos-Cejudo; Laura Otero-Ortega; Blanca Fuentes; María Teresa Vallejo-Cremades; Borja Enrique Sanz-Cuesta; Exuperio Díez-Tejedor;
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年(卷),期 2015(13),-1
年度 2015
页码 46
总页数 10
原文格式 PDF
正文语种
中图分类医学史;
关键词
Allogeneic and xenogeneic AD-MSCs Functional recovery Safety Stroke;

机译：同种和异种AD-MSC;功能恢复;安全性;中风;

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1. Comparison between xenogeneic and allogeneic adipose mesenchymal stem cells in the treatment of acute cerebral infarct: proof of concept in rats [J] . María Gutiérrez-Fernández, Berta Rodríguez-Frutos, Jaime Ramos-Cejudo, Journal of Translational Medicine . 2015,第1期

机译：异基因和异体脂肪间充质干细胞治疗急性脑梗死的比较：概念验证的大鼠
2. Comparative Efficacies of Long-Term Serial Transplantation of Syngeneic, Allogeneic, Xenogeneic, or CTLA4Ig-Overproducing Xenogeneic Adipose Tissue-Derived Mesenchymal Stem Cells on Murine Systemic Lupus Erythematosus [J] . Choi Eun Wha, Lee Hee Woo, Shin Il Seob, Cell transplantation . 2016,第6期

机译：在小鼠系统性红斑狼疮上长期连续移植同基因，异基因，异种或CTLA4Ig高产异种脂肪组织来源的间充质干细胞的连续功效。
3. Immunological effects of the intraparenchymal administration of allogeneic and autologous adipose-derived mesenchymal stem cells after the acute phase of middle cerebral artery occlusion in rats [J] . Zhang Yu, Tang Wenyan, Su Xuewen, Journal of Translational Medicine . 2018,第1期

机译：大脑中动脉闭塞急性期后同种异体和自体脂肪间充质干细胞实质性给药的大鼠的免疫学作用
4. Joint Segmentation of Intracerebral Hemorrhage and Infarct from Non-Contrast CT Images of Post-treatment Acute Ischemic Stroke Patients [C] . Hulin Kuang, Mohamed Najm, Bijoy K. Menon, International conference on medical imaging computing and computer-assisted intervention . 2018

机译：急性缺血性脑卒中患者的非对比CT图像对脑出血和梗塞的联合分割
5. Comparison of Platelet-rich Plasma, Bone Marrow Mesenchymal Stem Cells, Adipose-derived Mesenchymal Stem Cells, and Placebo in the Treatment of Knee Osteoarthritis [D] . Bach, Oscar. 2020

机译：富含血小板血浆，骨髓间充质干细胞，脂肪衍生间充质干细胞，安慰剂治疗膝关节骨关节炎的比较
6. Immunological effects of the intraparenchymal administration of allogeneic and autologous adipose-derived mesenchymal stem cells after the acute phase of middle cerebral artery occlusion in rats [O] . Zhang Yu, Tang Wenyan, Su Xuewen, 2018

机译：大脑中动脉阻塞急性期后同种异体和自体脂肪间充质干细胞实质性给药的大鼠的免疫学作用
7. Comparison between xenogeneic and allogeneic adipose mesenchymal stem cells in the treatment of acute cerebral infarct: proof of concept in rats [O] . María Gutiérrez-Fernández, Berta Rodríguez-Frutos, Jaime Ramos-Cejudo, 2015

机译：异源和异源脂肪间充质干细胞治疗急性脑梗死的比较：概念验证的大鼠

Comparison between xenogeneic and allogeneic adipose mesenchymal stem cells in the treatment of acute cerebral infarct: proof of concept in rats

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