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An intronic region within the human factor VIII gene is duplicated within Xq28 and is homologous to the polymorphic locus DXS115 (767)

机译：人凝血因子VIII基因中的一个内含子区域在Xq28中重复并且与多态性基因座DXS115（767）同源

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The genomic sequences recognized by the anonymous probe 767 (DXS115) are localized to two sites within Xq28. One site lies within intron 22 of the factor VIII gene (FBC). Physical mapping suggests that the second site lies within 1.2 megabases of the F8C gene. The RFLPs detected by 767 are located within the second site. Genetic data suggest that F8C and DXS115 are tightly linked (θmax = .04; Zmax = 8.30). Recombination events in meioses informative for DXS52 (Stl4), DXS115, and F8C suggest that DXS115 and F8C lie distal to DXS52.

机译：由匿名探针767（DXS115）识别的基因组序列位于Xq28内的两个位点。一个位点位于因子VIII基因（FBC）的内含子22内。物理作图表明第二个位点位于F8C基因的1.2兆碱基内。 767检测到的RFLP位于第二站点内。遗传数据表明F8C和DXS115是紧密相连的（θmax= .04； Zmax = 8.30）。有关DXS52（Stl4），DXS115和F8C的信息丰富的重组事件表明DXS115和F8C位于DXS52的远端。

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期刊名称 American Journal of Human Genetics
作者
M. Patterson; J. Gitschier; J. Bloomfield; M. Bell; H. Dorkins; U. Froster-Iskenius; S. Sommer; J. Sobell; D. Schaid; S. Thibodeau; K. E. Davies;
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年(卷),期 1989(44),5
年度 1989
页码 679–685
总页数 7
原文格式 PDF
正文语种
中图分类遗传学 ;
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专利

1. Five int22h homologous copies at the Xq28 locus identified in intron22 inversion type 3 of the Factor VIII gene [J] . Lannoy N., Ravoet M., Grisart B., Thrombosis Research: An International Journal on Vascular Obstruction, Hemorrhage and Hemostasis . 2016 ,第1期

机译：Xq28基因座的五个int22h同源拷贝在因子VIII基因的intron22倒置3型中鉴定
2. Five int22h homologous copies at the Xq28 locus identified in intron22 inversion type 3 of the Factor VIII gene [J] . Lannoy N., Ravoet M., Grisart B., Thrombosis Research: An International Journal on Vascular Obstruction, Hemorrhage and Hemostasis . 2016 ,第1期

机译：在因子VIII基因的Intron22反转型中鉴定的XQ28基因座的五个Int22H同源拷贝
3. Severe hemophilia A due to a 1.3 kb factor VIII gene deletion including exon 24: homologous recombination between 41 bp within an Alu repeat sequence in introns 23 and 24. [J] . Nakaya SM, Hsu TC, Geraghty SJ, Journal of thrombosis and haemostasis: JTH . 2004 ,第11期

机译：由于1.3 kb因子VIII基因缺失（包括外显子24）而导致的严重血友病A：内含子23和24中Alu重复序列中41 bp之间的同源重组。
4. Co-occurrence of core of binding sites for transcription factors in intronic region of Saccharomyces cerevisiae ribosomal protein genes [C] . Hu Jun, Zhang Jing 2010 International Conference on Bioinformatics and Biomedical Technology (ICBBT 2010) . 2010

机译：酿酒酵母核糖体蛋白基因内含子区域转录因子结合位点核心的共存
5. Patterns of nucleotide variability within and around G6PD, a locus under positive natural selection in humans. [D] . Saunders, Matthew Allan. 2004

机译：G6PD内和周围的核苷酸变异性模式，G6PD是人类正向自然选择下的一个基因座。
6. A 1.6-Mb contig of yeast artificial chromosomes around the human factor VIII gene reveals three regions homologous to probes for the DXS115 locus and two for the DXYS64 locus. [O] . D Freije, D Schlessinger 1992

机译：人类因子VIII基因周围的1.6 Mb酵母人工染色体重叠群揭示了三个与DXS115基因座的探针同源的区域和两个DXYS64基因座的探针同源的区域。
7. Severe hemophilia A due to a 1.3 kb factor VIII gene deletion including exon 24: homologous recombination between 41 bp within an Alu repeat sequence in introns 23 and 24 [O] . S. M. Nakaya, T.-C. Hsu, S. J. Geraghty, 2004

机译：严重的血友病A由于1.3 kB因子VIII基因缺失，包括外显子24：在内含子23和24中的ALU重复序列中的41bp之间的同源重组

An intronic region within the human factor VIII gene is duplicated within Xq28 and is homologous to the polymorphic locus DXS115 (767)

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