Design Synthesis and Analysis of Minor Groove Binder Pyrrolepolyamide-2′-Deoxyguanosine Hybrids

摘要

Pyrrolepolyamide-2′-deoxyguanosine hybrids (Hybrid >2 and Hybrid >3) incorporating the 3-aminopropionyl or 3-aminopropyl linker were designed and synthesized on the basis of previously reported results of a pyrrolepolyamide-adenosine hybrid (Hybrid >1). Evaluation of the DNA binding sequence selectivity of pyrrolepolyamide-2′-deoxyguanosine hybrids was performed by CD spectral and Tm analyses. It was shown that Hybrid >3 possessed greater binding specificity than distamycin A, Hybrid >1 and Hybrid >2.