Physiologically Based Pharmacokinetic (PBPK) Model for Biodistribution of Radiolabeled Peptides in Patients with Neuroendocrine Tumours

机译：基于生理学的药代动力学（PBPK）模型用于神经内分泌肿瘤患者中放射性标记肽的生物分布

代理获取

本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。

页面导航

摘要
著录项
相似文献
相关主题

摘要

Objective(s):The objectives of this work was to assess the benefits of the application of Physiologically Based Pharmacokinetic (PBPK) models in patients with different neuroendocrine tumours (NET) who were treated with Lu-177 DOTATATE. The model utilises clinical data on biodistribution of radiolabeled peptides (RLPs) obtained by whole body scintigraphy (WBS) of the patients.

机译：目的：这项工作的目的是评估在以Lu-177 DOTATATE治疗的不同神经内分泌肿瘤（NET）患者中应用基于生理的药代动力学（PBPK）模型的益处。该模型利用通过患者的全身闪烁扫描（WBS）获得的放射性标记肽（RLP）生物分布的临床数据。

著录项

期刊名称 Asia Oceania Journal of Nuclear Medicine and Biology
作者
Radovan Gospavic; Peter Knoll; Siroos Mirzaei; Viktor Popov;
展开▼
作者单位

展开▼
年(卷),期 2016(4),2
年度 2016
页码 90–97
总页数 8
原文格式 PDF
正文语种
中图分类放射医学;影像诊断学;
关键词
Lu-177 DOTATATE PBPK model Radiolabeled peptides Whole body scintigraphy;

机译：Lu-177 DOTATATE;PBPK模型;放射性标记的肽;全身闪烁显像;

相似文献

外文文献
中文文献
专利

1. Physiologically Based Pharmacokinetic (PBPK) model for biodistribution of radiolabeled peptides in patients with neuroendocrine tumours [J] . Viktor Popov, Radovan Gospavic, Peter Knoll, Asia Oceania Journal of Nuclear Medicine & Biology . 2016,第2期

机译：基于生理学的药代动力学（PBPK）模型在神经内分泌肿瘤患者中放射性标记肽的生物分布
2. PHYSIOLOGICALLY-BASED PHARMACOKINETIC (PBPK) MODELING AND SIMULATION OF PHARMACOKINETICS OF HEPATITIS C NS5A PROTEIN INHIBITORS IN NON-CIRRHOTIC HEPATITIS C VIRUS (HCV) PATIENTS AND PATIENTS WITH HEPATIC IMPAIRMENT. [J] . Wang Y., Gao W., Feng H., Clinical Pharmacology and Therapeutics . 2020,第S1期

机译：非肝硬化丙型肝炎病毒（HCV）患者丙型肝炎蛋白质蛋白抑制剂丙型肝炎药代动力学（PBPK）模拟及模拟。
3. Predicting the Effect of CYP3A Inducers on the Pharmacokinetics of Substrate Drugs Using Physiologically Based Pharmacokinetic (PBPK) Modeling: An Analysis of PBPK Submissions to the US FDA [J] . Wagner Christian, Pan Yuzhuo, Hsu Vicky, Clinical pharmacokinetics . 2016,第4期

机译：使用基于生理学的药代动力学（PBPK）建模预测CYP3A诱导剂对底物药物的药代动力学的影响：PBPK提交给美国FDA的分析
4. Application of physiologically based pharmacokinetic (PBPK) modeling to predict the distribution of trichloroethylene in different tissues of young male rats [C] . Sattar K.Alcasey, Elise M.Westmeyer, Jane Ellen Simmons, Bioengineering conference . 1999

机译：生理药代动力学（PBPK）模型在预测三氯乙烯在年轻雄性大鼠不同组织中的分布中的应用
5. Mechanistic Physiologically Based Pharmacokinetic (PBPK) Modeling of Renal and Systemic Disposition of Drugs and Metabolites [D] . Huang, Weize. 2020

机译：基于机械生理学的药代动力学（PBPK）肾脏肾和药物分配的建模
6. Physiologically-Based Pharmacokinetic (PBPK) Modeling Providing Insights into Fentanyl Pharmacokinetics in Adults and Pediatric Patients [O] . Lukas Kovar, Andreas Weber, Michael Zemlin, 2020

机译：基于生理学的药代动力学（PBPK）建模在成人和儿科患者中提供芬太尼药代动力学的见解
7. Physiologically-based Pharmacokinetic (PBPK) Modeling for Prediction of the Optimal Dose Regimens of Quinine and Phenobarbital Co-administration in Adult Patients with Cerebral Malaria and Seizures [O] . Teerachat Saeheng, Juntra Karbwang, Rajith Kumar Reddy Rajoli, 2020

机译：基于生理学的药代动力学（PBPK）模型，用于预测成年患者脑疟疾和癫痫发作中喹啉和苯酚生物共产管患者的最佳剂量方案
8. Availability of Acute and/or Subacute Toxicokinetic Data for Select Compounds for the Rat and Physiologically Based Pharmacokinetic (PBPK) Models for Rats and Humans for Those Compounds. [R] . Sweeney, L. M., Goodwin, M. R. 2017

机译：用于大鼠的选择化合物的急性和/或亚急性毒代动力学数据的可用性和用于那些化合物的大鼠和人的基于生理学的药代动力学（pBpK）模型。

Physiologically Based Pharmacokinetic (PBPK) Model for Biodistribution of Radiolabeled Peptides in Patients with Neuroendocrine Tumours

摘要

著录项

相似文献

相关主题

期刊订阅