Measurement of CO3-610 a Potential Liver Biomarker Derived from Matrix Metalloproteinase-9 Degradation of Collagen Type III in a Rat Model of Reversible Carbon-Tetrachloride-Induced Fibrosis

摘要

Background and aim:The current study utilized a carbon tetrachloride (CCl4)-induced liver fibrosis model to measure levels of the MMP9-mediated collagen type III degradation fragment CO3-610 (site of cleavage: KNGETGPQGP), during disease progression and regression, and to investigate a potential prognostic role of the biomarker.