Bayesian estimation of scaled mutation rate under the coalescent: a sequential Monte Carlo approach

摘要

BackgroundSamples of molecular sequence data of a locus obtained from random individuals in a population are often related by an unknown genealogy. More importantly, population genetics parameters, for instance, the scaled population mutation rate Θ=4N e μ for diploids or Θ=2N e μ for haploids (where N e is the effective population size and μ is the mutation rate per site per generation), which explains some of the evolutionary history and past qualities of the population that the samples are obtained from, is of significant interest.