Clinical bioinformatics for complex disorders: a schizophrenia case study

摘要

BackgroundIn the diagnosis of complex diseases such as neurological pathologies, a wealth of clinical and molecular information is often available to help the interpretation. Yet, the pieces of information are usually considered in isolation and rarely integrated due to the lack of a sound statistical framework. This lack of integration results in the loss of valuable information about how disease associated factors act synergistically to cause the complex phenotype.