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Day-to-day variations during clinical drug monitoring of morphine morphine-3-glucuronide and morphine-6-glucuronide serum concentrations in cancer patients. A prospective observational study

机译：癌症患者中吗啡吗啡-3-葡糖醛酸和吗啡-6-葡糖醛酸血清浓度的临床药物监测期间的每日变化。前瞻性观察研究

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摘要

BackgroundThe feasibility of drug monitoring of serum concentrations of morphine, morphine-6-glucuronide (M6G) and morphine-3-glucuronide (M3G) during chronic morphine therapy is not established. One important factor relevant to drug monitoring is to what extent morphine, M6G and M3G serum concentrations fluctuate during stable morphine treatment.

机译：背景技术在吗啡，吗啡-6-葡萄糖醛酸（M6G）和吗啡-3-葡萄糖醛酸（M3G）慢性吗啡治疗期间监测药物浓度的可行性尚未建立。与药物监测有关的一个重要因素是稳定吗啡治疗期间吗啡，M6G和M3G血清浓度的波动程度。

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期刊名称 BMC Pharmacology Toxicology
作者
Pål Klepstad; Priscilla Hilton; Jorunn Moen; Stein Kaasa; Petter C Borchgrevink; Kolbjørn Zahlsen; Ola Dale;
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作者单位

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年(卷),期 2004(4),-1
年度 2004
页码 7
总页数 7
原文格式 PDF
正文语种
中图分类药学;
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专利

1. HPLC determination of morphine, morphine-3-glucuronide and morphine-6-glucuronide in human serum of oncological patients after administration of morphine drugs. [J] . Netriova J, Blahova E, Johanesova Z, Die Pharmazie . 2006,第6期

机译：高效液相色谱法测定吗啡药物给药后肿瘤患者人血清中的吗啡，吗啡-3-葡糖醛酸和吗啡-6-葡糖醛酸。
2. Plasma concentrations of morphine, morphine-6-glucuronide and morphine-3-glucuronide and their relationship with analgesia and side effects in patients with cancer-related pain. [J] . Quigley C, Joel S, Patel N, Palliative medicine . 2003,第2期

机译：癌症相关疼痛患者的吗啡，吗啡-6-葡萄糖醛酸和吗啡-3-葡萄糖醛酸的血浆浓度及其与镇痛作用和副作用的关系。
3. Relationships between plasma concentrations of morphine, morphine-3-glucuronide, morphine-6-glucuronide, and intravenous morphine titration outcomes in the postoperative period. [J] . Hammoud HA, Aymard G, Lechat P, Fundamental & clinical pharmacology. . 2011,第4期

机译：术后血浆吗啡，吗啡-3-葡萄糖醛酸，吗啡-6-葡萄糖醛酸的浓度与静脉内吗啡滴定结果之间的关系。
4. Research on variations of serum concentrations of divalent cations for patients with malignant cancers of the oro-maxillo-facial area [C] . Elena Luca, Ioana Grigore, Maria-Antonela Beldiman IEEE International Conference on E-Health and Bioengineering . 2015

机译：口腔颌面部恶性肿瘤患者血清二价阳离子浓度变化的研究
5. Amiodarone toxicity: Relationships to cumulative dose and serum drug concentrations with preliminary observations of changes in superoxide dismutase activity. [D] . Pollak, Paul Timothy. 1988

机译：胺碘酮毒性：与累积剂量和血清药物浓度的关系，以及超氧化物歧化酶活性变化的初步观察。
6. Plasma morphine-3-glucuronide morphine-6-glucuronide and morphine concentrations in patients receiving long-term epidural morphine. [O] . J J Schneider, P J Ravenscroft, J D Cavenagh, 1992

机译：接受长期硬膜外吗啡治疗的患者血浆吗啡-3-葡糖醛酸吗啡-6-葡糖醛酸和吗啡浓度。
7. Day-to-day variations during clinical drug monitoring of morphine, morphine-3-glucuronide and morphine-6-glucuronide serum concentrations in cancer patients. A prospective observational study [O] . Pål Klepstad, Priscilla Hilton, Jorunn Moen, 2004

机译：癌症患者中吗啡，吗啡-3-葡糖醛酸和吗啡-6-葡糖醛酸血清浓度的临床药物监测期间的每日变化。前瞻性观察研究

Day-to-day variations during clinical drug monitoring of morphine morphine-3-glucuronide and morphine-6-glucuronide serum concentrations in cancer patients. A prospective observational study

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