Relationships between plasma concentrations of morphine, morphine-3-glucuronide, morphine-6-glucuronide, and intravenous morphine titration outcomes in the postoperative period.

Hammoud HA; Aymard G; Lechat P; Boccheciampe N; Riou B; Aubrun F

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Relationships between plasma concentrations of morphine, morphine-3-glucuronide, morphine-6-glucuronide, and intravenous morphine titration outcomes in the postoperative period.

机译：术后血浆吗啡，吗啡-3-葡萄糖醛酸，吗啡-6-葡萄糖醛酸的浓度与静脉内吗啡滴定结果之间的关系。

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Although intravenous morphine titration (IMT) is widely used to control moderate to severe postoperative pain, the relationships between plasma concentrations of morphine and its metabolites, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G), and IMT outcomes in the postanesthesia care unit (PACU) have not been yet investigated. IMT was administrated as a bolus of 2 or 3 mg every 5 min. Titration was interrupted in case of pain relief (visual analog score

机译：尽管静脉内吗啡滴定（IMT）被广泛用于控制中度至重度术后疼痛，但是吗啡及其代谢产物，吗啡-3-葡糖醛酸（M3G）和吗啡-6-葡糖醛酸（M6G）的血浆浓度与IMT结果之间的关系麻醉后护理病房（PACU）中尚未进行过调查。每5分钟以2或3 mg推注的方式给予IMT。如果疼痛缓解（视觉模拟评分

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《Fundamental & clinical pharmacology.》 |2011年第4期|共10页
作者
Hammoud HA; Aymard G; Lechat P; Boccheciampe N; Riou B; Aubrun F;
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正文语种 eng
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1. Relationships between plasma concentrations of morphine, morphine-3-glucuronide, morphine-6-glucuronide, and intravenous morphine titration outcomes in the postoperative period. [J] . Hammoud HA, Aymard G, Lechat P, Fundamental & clinical pharmacology. . 2011,第4期

机译：术后血浆吗啡，吗啡-3-葡萄糖醛酸，吗啡-6-葡萄糖醛酸的浓度与静脉内吗啡滴定结果之间的关系。
2. Plasma concentrations of morphine, morphine-6-glucuronide and morphine-3-glucuronide and their relationship with analgesia and side effects in patients with cancer-related pain. [J] . Quigley C, Joel S, Patel N, Palliative medicine . 2003,第2期

机译：癌症相关疼痛患者的吗啡，吗啡-6-葡萄糖醛酸和吗啡-3-葡萄糖醛酸的血浆浓度及其与镇痛作用和副作用的关系。
3. Determination of morphine, morphine-3-glucuronide, and morphine-6-glucuronide in plasma after intravenous and intrathecal morphine administration using HPLC with electrospray ionization and tandem mass spectrometry. [J] . Slawson MH, Crouch DJ, Andrenyak DM, Journal of Analytical Toxicology . 1999,第6期

机译：使用电喷雾电离和串联质谱的HPLC测定静脉内和鞘内注射吗啡后血浆中的吗啡，吗啡3-葡糖醛酸和吗啡6-葡糖醛酸。
4. Determination of Morphine and Its Metabolites Morphine 3-Glucuronide and Morphine 6-Glucuronide in Human Plasma by LC-MS/MS [C] . Vivek Tummala, Sherwin Jiang, Robert Harman, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2009

机译：通过LC-MS / MS测定吗啡及其代谢物吗啡3-葡糖苷和吗啡6-葡糖醛酸酯
5. The role of morphine-3-glucuronide, morphine-6-glucuronide, and gender differences in morphine analgesia in rats and humans. [D] . Baker, Lanning. 2002

机译：吗啡镇痛作用在大鼠和人类中，吗啡-3-葡糖醛酸，吗啡-6-葡糖醛酸的作用和性别差异。
6. Plasma morphine-3-glucuronide morphine-6-glucuronide and morphine concentrations in patients receiving long-term epidural morphine. [O] . J J Schneider, P J Ravenscroft, J D Cavenagh, 1992

机译：接受长期硬膜外吗啡治疗的患者血浆吗啡-3-葡糖醛酸吗啡-6-葡糖醛酸和吗啡浓度。
7. Plasma morphine-3-glucuronide, morphine-6-glucuronide and morphine concentrations in patients receiving long-term epidural morphine. [O] . Schneider, J J, Ravenscroft, P J, Cavenagh, J D, 1992

机译：接受长期硬膜外吗啡治疗的患者血浆吗啡-3-葡糖醛酸，吗啡-6-葡糖醛酸和吗啡浓度。

Relationships between plasma concentrations of morphine, morphine-3-glucuronide, morphine-6-glucuronide, and intravenous morphine titration outcomes in the postoperative period.

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