Transcriptional signatures of Itk-deficient CD3+ CD4+ and CD8+ T-cells

摘要

BackgroundThe Tec-family kinase Itk plays an important role during T-cell activation and function, and controls also conventional versus innate-like T-cell development. We have characterized the transcriptome of Itk-deficient CD3⁺ T-cells, including CD4⁺ and CD8⁺ subsets, using Affymetrix microarrays.