Ascending central canal dilation and progressive ependymal disruption in a contusion model of rodent chronic spinal cord injury

摘要

BackgroundChronic spinal cord injury (SCI) can lead to an insidious decline in motor and sensory function in individuals even years after the initial injury and is accompanied by a slow and progressive cytoarchitectural destruction. At present, no pathological mechanisms satisfactorily explain the ongoing degeneration.