Insulin transport across the blood–brain barrier can occur independently of the insulin receptor

摘要

Key points class="unordered" style="list-style-type:disc" id="tjp13168-list-0001">Insulin enters the brain from the blood via a saturable transport system.It is unclear how insulin is transported across the blood–brain barrier (BBB).Using two models of the signalling‐related insulin receptor loss or inhibition, we show insulin transport can occur in vivo without the signalling‐related insulin receptor.Insulin in the brain has multiple roles including acting as a metabolic regulator and improving memory.Understanding how insulin is transported across the BBB will aid in developing therapeutics to further increase CNS concentrations.