首页> 外国专利> insulin analogue, pharmaceutical composition, method for treating and / or preventing an insulin related condition, method for decreasing blood glucose levels, use of insulin analogue, replanning method or modification of a polypeptide which is known to bind to an insulin receptor, polypeptide, isolated molecule, method for identifying a compound that binds to the insulin receptor, computer based method for identifying a compound that mimics insulin activity, compound identified using a method, polypeptide crystal, structure of the polypeptide, use of structure, use of structural model, peptide, method for increasing insulin receptor activation in a subject, method for lowering blood sugar in a subject, method for treating type 1 diabetes in a subject, and therapeutic protein

insulin analogue, pharmaceutical composition, method for treating and / or preventing an insulin related condition, method for decreasing blood glucose levels, use of insulin analogue, replanning method or modification of a polypeptide which is known to bind to an insulin receptor, polypeptide, isolated molecule, method for identifying a compound that binds to the insulin receptor, computer based method for identifying a compound that mimics insulin activity, compound identified using a method, polypeptide crystal, structure of the polypeptide, use of structure, use of structural model, peptide, method for increasing insulin receptor activation in a subject, method for lowering blood sugar in a subject, method for treating type 1 diabetes in a subject, and therapeutic protein

机译:胰岛素类似物,药物组合物,治疗和/或预防胰岛素相关病症的方法,降低血糖水平的方法,胰岛素类似物的使用,重新规划方法或已知与胰岛素受体结合的多肽的修饰,多肽分子,鉴定与胰岛素受体结合的化合物的方法,基于计算机的鉴定模拟胰岛素活性的化合物的方法,使用方法鉴定的化合物,多肽晶体,多肽的结构,结构的使用,结构模型的使用,肽,在受试者中增加胰岛素受体活化的方法,在受试者中降低血糖的方法,在受试者中治疗1型糖尿病的方法和治疗性蛋白质

摘要

The present invention relates to insulin analogs, particularly insulin analogs having shortened b chains. The present invention also relates to the crystal structure of conidial venom insulin and methods of using crystal and related structural information to track and design insulin analogues that interact with or modulate the insulin receptor. The present invention also relates to therapeutic and prophylactic methods using insulin analogs.
机译:本发明涉及胰岛素类似物,特别是具有缩短的b链的胰岛素类似物。本发明还涉及分生孢子毒胰岛素的晶体结构以及使用晶体和相关结构信息来跟踪和设计与胰岛素受体相互作用或调节胰岛素受体的胰岛素类似物的方法。本发明还涉及使用胰岛素类似物的治疗和预防方法。

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