Depletion of Pax7+ satellite cells does not affect diaphragm adaptations to running in young or aged mice

摘要

Key points class="unordered" style="list-style-type:disc" id="tjp12524-list-0001">Satellite cell depletion does not affect diaphragm adaptations to voluntary wheel running in young or aged mice.Satellite cell depletion early in life (4 months of age) has minimal effect on diaphragm phenotype by old age (24 months).Prolonged satellite cell depletion in the diaphragm does not result in excessive extracellular matrix accumulation, in contrast to what has been reported in hind limb muscles.Up‐regulation of Pax3 mRNA+ cells after satellite cell depletion in young and aged mice suggests that Pax3+ cells may compensate for a loss of Pax7+ satellite cells in the diaphragm.Future investigations should focus on the role of Pax3+ cells in the diaphragm during adaptation to exercise and ageing.