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Transgenic mice depleted in mature T-cells and methods for making transgenic mice
Transgenic mice depleted in mature T-cells and methods for making transgenic mice
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机译:耗尽成熟T细胞的转基因小鼠及其制备方法
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摘要
Transgenic mice having a phenotype characterized by the substantial absence of mature T lymphocytes otherwise naturally occurring in said mice. The phenotype is conferred in the transgenic mouse by a transgene contained in at least the precursor stem cell of the T lymphocyte which is depleted. The transgene comprises a DNA sequence encoding a T cell receptor polypeptide variant which inhibits maturation of the T lymphocyte.
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