Expressions of iron metabolism related proteins in the spinal cord of amyotrophic lateral sclerosis transgenic mice

摘要

To verify the dynamic expressions of iron transporters during ALS progression,we investigated the expression and co-localization of divalent metal transporter 1(DMT1),ferroportin 1(FPN1)and iron regulatory protein 1(IRP1)in the spinal cord of transgenic mice harboring hSOD1G93A gene mutation(ALS mice)and non-transgenic littermates(WT mice)at 70 d,95 d and 122 d.Western blotting showed that in spinal cord of ALS mice,DMT1 was down-regulated from 70 d.FPN1 was transiently up-regulated at 70 d,and declined at 95 d and 122 d.