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Transgenic mice depleted in a mature lymphocytic cell-type
Transgenic mice depleted in a mature lymphocytic cell-type
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机译:耗尽成熟淋巴细胞型的转基因小鼠
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摘要
Transgenic mice having a phenotype characterized by the substantial depletion of a mature lymphocytic cell type otherwise naturally occurring in the species from which the transgenic mouse is derived. The phenotype is conferred in the transgenic mouse by a transgene contained in at least the precursor stem cell of the lymphocytic cell type which is depleted. The transgene comprises a DNA sequence encoding a lymphatic polypeptide variant which inhibits maturation of the lymphocytic cell type.
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