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Analysis of naltrexone and its metabolite 6-beta-naltrexol in serum with high-performance liquid chromatography

机译：高效液相色谱法分析血清中的纳曲酮及其代谢物6-β-纳曲酮

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摘要

BackgroundNaltrexone has been proven to be an effective treatment option for the treatment of alcohol dependency. In this article we introduce a reliable and simple method developed for the simultaneous determination of naltrexone and 6-β-naltrexol in human serum by using high-performance liquid chromatography (HPLC).

机译：背景已证明纳曲酮是用于治疗酒精依赖的有效治疗选择。在本文中，我们介绍了一种可靠而简单的方法，该方法通过使用高效液相色谱（HPLC）同时测定人血清中的纳曲酮和6-β-纳曲醇。

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期刊名称 BMC Research Notes
作者
Pekka Heinälä; Tuuli Lahti; David Sinclair; Kari Ariniemi; Pirjo Lillsunde; Hannu Alho;
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年(卷),期 2012(5),-1
年度 2012
页码 439
总页数 5
原文格式 PDF
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关键词
Naltrexone 6-β-naltrexol High-performance liquid chromatography Alcoholism;

机译：纳曲酮;6-β-纳曲醇;高效液相色谱法;酒精中毒;

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专利

1. Simultaneous analysis of naltrexone and its major metabolite,6-beta-naltrexol,in human plasma using liquid chromatography-tandem mass spectrometry: Application to a parent-metabolite kinetic model in humans [J] . Hwi-yeol Yun, Seong-chul Bang, Ki-cheol Lee Talanta: The International Journal of Pure and Applied Analytical Chemistry . 2007,第4期

机译：液相色谱-串联质谱法同时分析人血浆中的纳曲酮及其主要代谢物6-β-纳曲酮：在人母体代谢动力学模型中的应用
2. Analysis of naltrexone and its metabolite 6-β-naltrexol in serum with high-performance liquid chromatography [J] . Pekka Hein?l?, Tuuli Lahti, David Sinclair, BMC research notes . 2012,第1期

机译：高效液相色谱法分析血清中的纳曲酮及其代谢物6-β-纳曲醇
3. High-performance liquid chromatography-mass spectrometric analysis of ramipril and its active metabolite ramiprilat in human serum: application to a pharmacokinetic study in the Chinese volunteers. [J] . Lu XY, Shen Tu JZ, Liu J Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis . 2006,第2期

机译：雷米普利及其活性代谢物雷米普利拉特在人血清中的高效液相色谱-质谱分析：在中国志愿者的药代动力学研究中的应用。
4. ON-LINE CLEAN-UP BY COLUMN SWITCHING LIQUID CHROMATOGRAPHY ATMOSPHERE PRESSURE CHEMICAL IONIZATION TRAP MASS SPECTROMETRY FOR QUANTIFICATION OF AMYGDALIN AND QUALITATIVE ANALYSIS OF ITS METABOLITES IN RABBIT SERUM [C] . . 2005

机译：柱切换液相色谱-大气压力化学电离阱质谱在线纯化杏仁油中淀粉样蛋白的含量和定性分析
5. High-performance liquid chromatography analysis of fatty acids and mathematical modeling of liquid chromatography. [D] . Li, Zhiguo. 2001

机译：脂肪酸的高效液相色谱分析和液相色谱的数学模型。
6. Residue analysis and persistence evaluation of fipronil and its metabolites in cotton using high-performance liquid chromatography-tandem mass spectrometry [O] . Xiaohu Wu, Yang Yu, Jun Xu, 2012

机译：高效液相色谱-串联质谱法测定棉花中氟虫腈及其代谢物的残留量和持久性评价
7. Analysis of naltrexone and its metabolite 6-beta-naltrexol in serum with high-performance liquid chromatography [O] . Pekka Heinälä, Tuuli Lahti, David Sinclair, 2012

机译：高效液相色谱法分析血清中的纳曲酮及其代谢物6-β-纳曲酮
8. Analysis of Organophosphorus Pesticide Samples by High-Performance Liquid Chromatography/Mass Spectrometry and High-Performance Liquid Chromatography/Mass Spectrometry/Mass Spectrometry [R] . Betowski, L. D., Jones, T. L. 1988

机译：有机磷农药样品的高效液相色谱/质谱分析及高效液相色谱/质谱/质谱分析

Analysis of naltrexone and its metabolite 6-beta-naltrexol in serum with high-performance liquid chromatography

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