Quality of tumor lysates used for pulsing dendritic cells is influenced by the method used to harvest adherent tumor cells

摘要

BackgroundLysates from tumor cells are reported to induce maturation of dendritic cells (DCs) and are used in clinical settings for DC-based vaccination against solid tumors. Nevertheless, the maturation inducing effect of tumor lysates on DCs is discussed controversially and the efficacy of tumor vaccines varies significantly.