Protocol for a systematic review and meta-analysis of fractional dose compared with standard dose inactivated polio vaccination in children

摘要

IntroductionWHO recommends the introduction of at least one single dose of inactivated polio vaccine (IPV) in routine immunisation schedules. Thus, there has been an increased demand and concurrent supply shortages of IPV worldwide. One of the strategies to improve access is the use of fractional instead of full doses of IPV. We aim to compare the effects of fractional with standard doses of IPV.