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Intratumoral concentration of estrogens and clinicopathological changes in ductal carcinoma in situ following aromatase inhibitor letrozole treatment

机译：芳香化酶抑制剂来曲唑治疗后肿瘤内雌激素浓度及导管癌原位的临床病理变化

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摘要

Background: Estrogens have important roles in ductal carcinoma in situ (DCIS) of the breast. However, the significance of presurgical aromatase inhibitor treatment remains unclear. Therefore, we examined intratumoral concentration of estrogens and changes of clinicopathological factors in DCIS after letrozole treatment.

机译：背景：雌激素在乳腺导管原位癌（DCIS）中具有重要作用。但是，术前芳香化酶抑制剂治疗的意义尚不清楚。因此，我们检查了来曲唑治疗后DCIS中雌激素的肿瘤内浓度和临床病理因素的变化。

著录项

期刊名称 British Journal of Cancer
作者
K Takagi; T Ishida; Y Miki; H Hirakawa; Y Kakugawa; G Amano; A Ebata; N Mori; Y Nakamura; M Watanabe; M Amari; N Ohuchi; H Sasano; T Suzuki;
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作者单位

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年(卷),期 2013(109),1
年度 2013
页码 100–108
总页数 9
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
aromatase breast carcinoma DCIS oestrogen induced gene letrozole;

机译：芳香化酶;乳腺癌;DCIS;雌激素;诱导基因;来曲唑;

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专利

1. Intratumoral concentration of estrogens and clinicopathological changes in ductal carcinoma in situ following aromatase inhibitor letrozole treatment [J] . K Takagi, T Ishida, Y Miki, British Journal of Cancer . 2013,第1期

机译：芳香化酶抑制剂来曲唑治疗后导管内原位癌的雌激素浓度和临床病理变化
2. Effects of SLCO1B1 polymorphisms on plasma estrogen concentrations in women with breast cancer receiving aromatase inhibitors exemestane and letrozole [J] . Dempsey Jacqueline M., Kidwell Kelley M., Gersch Christina L., Pharmacogenomics . 2019,第8期

机译：SLCO1B1多态性对接受芳香酶抑制剂的血浆雌激素浓度血浆酶促抑制剂的血浆雌激素浓度
3. Aromatase and in situ estrogen production in DCIS (ductal carcinoma in situ) of human breast [J] . SasanoH., MikiY., ShibuyaR., The Journal of Steroid Biochemistry and Molecular Biology . 2010,第4a5期

机译：人乳腺癌DCIS（导管原位癌）中芳香酶和原位雌激素的产生
4. Serum Biomarker Concentrations in Benign Breast Conditions and Ductal Carcinoma In Situ: Designing a Diagnostic Biomarker Panel That Can Distinguish Between Benign Conditions and Invasive Breast Cancer [C] . David E. Reese, Meredith C. Henderson, Susan Yeh, Molecular Medicine TRI-CON. . 2014

机译：血清生物标志物浓度在良性乳腺条件和导管癌原位：设计诊断生物标志物面板，可以区分良性条件和侵袭性乳腺癌
5. Do variations in treatment of ductal carcinoma in situ affect outcomes? [D] . Gold, Heather Taffet. 2002

机译：导管癌原位治疗的变化会影响预后吗？
6. COX-2 expression is predictive for early relapse and aromatase inhibitor resistance in patients with ductal carcinoma in situ of the breast and is a target for treatment [O] . D Generali, F M Buffa, S Deb, 2014

机译：COX-2表达可预测乳腺导管癌患者的早期复发和芳香化酶抑制剂耐药性是治疗的目标
7. COX-2 expression is predictive for early relapse and aromatase inhibitor resistance in patients with ductal carcinoma in situ of the breast, and is a target for treatment [O] . Generali, D, Buffa, F.M., Deb, S., 2014

机译：COX-2表达可预测乳腺导管癌患者的早期复发和芳香化酶抑制剂耐药性，是治疗的目标
8. Interaction of Dietary Genistein, Equol, and Aromatase Inhibitors on Growth of Estrogen-Dependent Human Breast Cancer (MCF-7Ca) Cell in Athymic Mice [R] . Chen, M. 2004

机译：膳食染料木黄酮，雌马酚和芳香酶抑制剂对无胸腺小鼠雌激素依赖性人乳腺癌（mCF-7Ca）细胞生长的影响

Intratumoral concentration of estrogens and clinicopathological changes in ductal carcinoma in situ following aromatase inhibitor letrozole treatment

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