Expansion of a PBPK model to predict disposition in pregnant women of drugs cleared via multiple CYP enzymes including CYP2B6 CYP2C9 and CYP2C19

摘要

AimConducting PK studies in pregnant women is challenging. Therefore, we asked if a physiologically-based pharmacokinetic (PBPK) model could be used to predict the disposition in pregnant women of drugs cleared by multiple CYP enzymes.