Assessment of the absorption metabolism and absolute bioavailability of maraviroc in healthy male subjects

摘要

AimsTwo studies were conducted to: (i) quantify the amount of drug-related radioactivity in blood, plasma, urine and faeces following a ¹⁴C-labelled dose of maraviroc; and (ii) investigate the pharmacokinetics, safety and tolerability of intravenous (i.v.) maraviroc and determine the absolute bioavailability of oral maraviroc. Metabolite profiling was also conducted. Data from both of these studies were used to construct a mass-balance model for maraviroc.