Pharmacokinetics and effect on caffeine metabolism of the proton pump inhibitors omeprazole lansoprazole and pantoprazole

摘要

AimsTo study the pharmacokinetics of three proton pump inhibitors, omeprazole, lansoprazole, and pantoprazole, as well as any potential influence on CYP1A2 activity (measured by means of rate of caffeine metabolism) of these compounds at single dose and repeated dose administration.