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Hyperprolactinemia-inducing antipsychotics increase breast cancer risk by activating JAK-STAT5 in precancerous lesions

机译：高催乳激素诱导的抗精神病药通过激活癌前病变中的JAK-STAT5增加乳腺癌的风险

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BackgroundPsychiatric medications are widely prescribed in the USA. Many antipsychotics cause serum hyperprolactinemia as an adverse side effect; prolactin-Janus kinase 2 (JAK2)-signal transducer and activator of transcription 5 (STAT5) signaling both induces cell differentiation and suppresses apoptosis. It is controversial whether these antipsychotics increase breast cancer risk.

机译：背景技术精神药物在美国被广泛地处方。许多抗精神病药会导致血清高泌乳素血症，这是不良的副作用。催乳素-Janus激酶2（JAK2）信号转导子和转录激活因子5（STAT5）信号转导细胞分化并抑制细胞凋亡。这些抗精神病药是否会增加患乳腺癌的风险，这是有争议的。

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期刊名称 Breast Cancer Research : BCR
作者
A. N. Johnston; W. Bu; S. Hein; S. Garcia; L. Camacho; L. Xue; L. Qin; C. Nagi; S. G. Hilsenbeck; J. Kapali; K. Podsypanina; J. Nangia; Y. Li;
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作者单位

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年(卷),期 2018(20),-1
年度 2018
页码 42
总页数 13
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
Cancer Breast cancer Antipsychotics Neuroleptics Prolactin STAT5 JAK Ruxolitinib Mammary gland;

机译：癌症;乳腺癌;抗精神病药;抗精神病药;催乳素;STAT5;JAK;鲁索替尼;乳腺;

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2. Breast MR imaging in women at increased lifetime risk of breast cancer: clinical system for computerized assessment of breast lesions initial results. [J] . Gilhuijs KG, Deurloo EE, Muller SH, Radiology . 2002,第3期

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3. Significant Family History of Breast Cancer may Further Increase Risk of Pre-malignant and Malignant Lesions in Specimens from Breast Reduction Surgery [J] . Altundag Kadri Pathology oncology research: POR . 2019,第4期

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4. Study on Screening Cervical Precancerous Lesions by High-risk Human Papillomavirus DNA Detection and Cytological Examination [C] . Lingling Tong, Xiaojun Liu International Conference on Biomedical Sciences and Information Systems;Hebei University of Science and Technology . 2019

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5. Precancerous lesions induced by cigarette smoke: Possible molecular mechanisms and prevention by dietary vitamin A intake but with potential osteoporotic risk [D] . Xue, Yuan. 2006

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6. Precancerous Gastric Lesions with Helicobacter pylori vacA+/babA2+/oipA+ Genotype Increase the Risk of Gastric Cancer [O] . Theeraya Simawaranon Bartpho, Wareeporn Wattanawongdon, Taweesak Tongtawee, 2020

机译：幽门螺杆菌vacA + / babA2 + / oipA +基因型的胃癌前病变会增加患胃癌的风险
7. Hyperprolactinemia-inducing antipsychotics increase breast cancer risk by activating JAK-STAT5 in precancerous lesions [O] . A. N. Johnston, W. Bu, S. Hein, 2018

机译：诱导高催乳素症的抗精神病药通过激活癌前病变中的JAK-Stat5增加乳腺癌风险
8. Population Based Assessment of MHC Class I Antigens Down Regulation as Markers of Increased Risk for Development and Progression of Breast Cancer from Benign Breast Lesions [R] . Worsham, M. J. 2007

机译：基于人群的mHC I类抗原下调作为良性乳腺病发展和乳腺癌进展风险增加的标志物的评估

Hyperprolactinemia-inducing antipsychotics increase breast cancer risk by activating JAK-STAT5 in precancerous lesions

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