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Targeting therapy of hepatocellular carcinoma with doxorubicin prodrug PDOX increases anti-metastatic effect and reduces toxicity: a preclinical study

机译：临床研究：阿霉素前药PDOX靶向治疗肝细胞癌可提高抗转移作用并降低毒性

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BackgroundThis study was to investigate the effects and safety of cathepsin B-cleavable doxorubicin (DOX)-prodrug (PDOX) for targeting therapy of metastatic human hepatocellular carcinoma (HCC) using DOX as a positive control drug.

机译：背景本研究旨在研究组织蛋白酶B可裂解的阿霉素（DOX）-前药（PDOX）在以DOX为阳性对照药物的转移性人肝癌（HCC）靶向治疗中的作用和安全性。

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期刊名称 Journal of Translational Medicine
作者
Qun Wang; Yan-Jun Zhong; Jing-Ping Yuan; Li-Hua Shao; Jue Zhang; Li Tang; Shao-Ping Liu; Ya-Ping Hong; Raymond A Firestone; Yan Li;
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作者单位

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年(卷),期 2013(11),-1
年度 2013
页码 192
总页数 12
原文格式 PDF
正文语种
中图分类医学史;
关键词
Hepatocellular carcinoma Molecular targeting therapy Doxorubicin PDOX Metastases;

机译：肝细胞癌;分子靶向治疗;阿霉素;PDOX;转移;

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专利

1. Targeting therapy of hepatocellular carcinoma with doxorubicin prodrug PDOX increases anti-metastatic effect and reduces toxicity: a preclinical study [J] . Qun Wang, Yan-Jun Zhong, Jing-Ping Yuan, Journal of Translational Medicine . 2013,第1期

机译：临床研究：阿霉素前药PDOX靶向治疗肝细胞癌可提高抗转移作用并降低毒性
2. Targeting therapy of hepatocellular carcinoma with doxorubicin prodrug PDOX increases anti-metastatic effect and reduces toxicity: a preclinical study [J] . Qun Wang, Yan-Jun Zhong, Jing-Ping Yuan, Journal of Translational Medicine . 2013,第1期

机译：临床研究：阿霉素前药PDOX靶向治疗肝细胞癌可提高抗转移作用并降低毒性
3. Hepatocellular Carcinoma in Children: Does Modified Platinum- and Doxorubicin-Based Chemotherapy Increase Tumor Resectability and Change Outcome? Lessons Learned From the SIOPEL 2 and 3 Studies [J] . Murawski Maciej, Weeda Viola B., Maibach Rudolf, Journal of Clinical Oncology . 2016,第10期

机译：儿童肝细胞癌：基于铂和阿霉素的改良化疗是否会增加肿瘤的可切除性并改变结果？从SIOPEL 2和3研究中学到的教训
4. Targeted Doxorubicin Delivery to Hepatocellular Carcinoma by Galactosylated Nanogel [C] . Juan Wu, Tian-Meng Sun, Meng-Hua Xiong, Annual meeting exposition of the Controlled Release Society . 2011

机译：半乳糖基化纳米凝胶靶向将阿霉素递送至肝癌
5. Transient increases in serum α fetoprotein and protein induced by vitamin K antagonist II levels following proton therapy does not necessarily indicate progression of hepatocellular carcinoma [D] . YOSHIDA MAIKO, 吉田舞子 2019

机译：质子治疗后血清α甲胎蛋白和维生素K拮抗剂II水平诱导的蛋白的短暂增加不一定表明肝细胞癌的进展
6. Synthesis, identification and in vivo studies of tumor-targeting agent peptide doxorubicin (PDOX) to treat peritoneal carcinomatosis of gastric cancer with similar efficacy but reduced toxicity [O] . Li Tang, Rui Duan, Yan-jun Zhong, 1971

机译：肿瘤靶向剂肽阿霉素（PDOX）治疗胃癌腹膜癌的合成，鉴定和体内研究具有相似的疗效，但毒性降低
7. Targeting therapy of hepatocellular carcinoma with doxorubicin prodrug PDOX increases anti-metastatic effect and reduces toxicity: a preclinical study [O] . 2013

机译：临床研究：阿霉素前药PDOX靶向治疗肝细胞癌可提高抗转移作用并降低毒性

Targeting therapy of hepatocellular carcinoma with doxorubicin prodrug PDOX increases anti-metastatic effect and reduces toxicity: a preclinical study

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