Understanding How Metabolites Link Diet Host and Microbiota in a Dysfunctional Gut Model Is Important to Establishing a System-wide Understanding of Gut Function (P20-035-19)

摘要

ObjectivesNutrition modulates the interactions between the host and the gut microbiota. Changes in metabolites resulting from this interaction in a healthy compared to a perturbed gut is a critical approach to identify putative biomarkers that can be used to assess how diet effects gut function. Bile acids (BAs) are metabolites produced from cholesterol and the microbial-conversion of BAs play an important role in digestion and metabolism. Modification of BA metabolism has been reported in participants with Irritable Bowel Syndrome (IBS), which is characterised by abdominal bloating, pain, dysfunction, and a perturbed gut microbiota. One aim of the clinical nutrition study was to characterise BA profiles of healthy control and IBS participants. This work is part of a wider study investigating gut health and how food can be used to alleviate symptoms.