Comparison of the protective efficacy between single and combination of recombinant adenoviruses expressing complete and truncated glycoprotein and nucleoprotein of the pathogenic street rabies virus in mice

摘要

BackgroundRabies is an important viral zoonosis that causes acute encephalitis and death in mammals. To date, several recombinant vaccines have been developed based on G protein, which is considered to be the main antigen, and these vaccines are used for rabies control in many countries. Most recombinant viruses expressing RABV G protein retain the G gene from attenuated RABV. Not enough is currently known about the protective effect against RABV of a combination of recombinant adenoviruses expressing the G and N proteins of pathogenic street RABV.