RNA interference-mediated silencing of eukaryotic translation initiation factor 3 subunit B (EIF3B) gene expression inhibits proliferation of colon cancer cells

摘要

BackgroundA key factor underlying the control of the cellular growth, size and proliferation involves the regulation of the total protein synthesis. Most often, the initial stages of mRNA translation are rate limiting, which involves a group of eukaryotic translation initiation factors (EIFs). Research advances focused on the inhibition of their expression and activity hold the key to the initiation and progression of tumor and tumor prognosis.