Thyroid hormone – triiodothyronine – has contrary effect on proliferation of human proximal tubules cell line (HK2) and renal cancer cell lines (Caki-2 Caki-1) – role of E2F4 E2F5 and p107 p130

摘要

BackgroundTriiodothyronine regulates proliferation acting as stimulator or inhibitor. E2F4 and E2F5 in complexes with pocket proteins p107 or p130 stop cells in G1, repressing transcription of genes important for cell cycle progression. p107 and p130 inhibits activity of cyclin/cdk2 complexes. Expression of all those proteins could be regulated by triiodothyronine. In clear cell renal cell carcinoma many disturbances in T3 signaling pathway was described, in that type of cancer also expression of some key G1 to S phase progression regulators was shown.