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A Versatile and Reproducible Multi-Frequency Electrical Impedance Tomography System

机译:多功能且可再现的多频率电阻抗层析成像系统

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摘要

A highly versatile Electrical Impedance Tomography (EIT) system, nicknamed the ScouseTom, has been developed. The system allows control over current amplitude, frequency, number of electrodes, injection protocol and data processing. Current is injected using a Keithley 6221 current source, and voltages are recorded with a 24-bit EEG system with minimum bandwidth of 3.2 kHz. Custom PCBs interface with a PC to control the measurement process, electrode addressing and triggering of external stimuli. The performance of the system was characterised using resistor phantoms to represent human scalp recordings, with an SNR of 77.5 dB, stable across a four hour recording and 20 Hz to 20 kHz. In studies of both haeomorrhage using scalp electrodes, and evoked activity using epicortical electrode mats in rats, it was possible to reconstruct images matching established literature at known areas of onset. Data collected using scalp electrode in humans matched known tissue impedance spectra and was stable over frequency. The experimental procedure is software controlled and is readily adaptable to new paradigms. Where possible, commercial or open-source components were used, to minimise the complexity in reproduction. The hardware designs and software for the system have been released under an open source licence, encouraging contributions and allowing for rapid replication.
机译:已经开发了一种绰号为ScouseTom的用途广泛的电阻抗层析成像(EIT)系统。该系统允许控制电流幅度,频率,电极数量,注入协议和数据处理。使用Keithley 6221电流源注入电流,并使用最小带宽为3.2 kHz的24位EEG系统记录电压。定制的PCB与PC相连,以控制测量过程,电极寻址和外部刺激的触发。该系统的性能使用电阻体模来表征人类头皮录音,其信噪比(SNR)为77.5 dB,在四个小时的录音中稳定,并且在20 Hz至20 kHz范围内保持稳定。在大鼠使用头皮电极出血和使用皮层电极垫诱发活动的研究中,有可能在已知的发病部位重建与既定文献相匹配的图像。在人类中使用头皮电极收集的数据与已知的组织阻抗谱相匹配,并且在整个频率范围内都是稳定的。实验程序是由软件控制的,并且很容易适应新的范例。尽可能使用商业或开源组件,以最大程度地减少复制的复杂性。该系统的硬件设计和软件已通过开源许可发布,这鼓励了人们的贡献并允许快速复制。

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