Synthesis and Anti-Inflammatory Activity of New Alkyl-Substituted Phthalimide 1H-123-Triazole Derivatives

摘要

Four new 1,2,3-triazole phthalimide derivatives with a potent anti-inflammatory activity have been synthesized in the good yields by the 1,3-dipolar cycloaddition reaction from N-(azido-alkyl)phthalimides and terminal alkynes. The anti-inflammatory activity was determined by injecting carrageenan through the plantar tissue of the right hind paw of Swiss white mice to produce inflammation. All the compounds >3a–c and >5a–c exhibited an important anti-inflammatory activity; the best activity was found for the compounds >3b and >5c, which showed to be able to decrease by 69% and 56.2% carrageenan-induced edema in mice. These compounds may also offer a future promise as a new anti-inflammatory agent.