PEPTIDE DERIVATIVES, THEIR STEREOISOMERS OR PHYSIOLOGICALLY ACCEPTABLE SALTS SHOWING ANTITHROMBOSIS, ANTICOAGULATING OR ANTI-INFLAMMATORY ACTIVITY, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION, METHOD OF SUPPRESSION OF THROMBIN ACTIVITY, METHOD OF INHIBITION OF KININOGENASES ACTIVITY, USE OF COMPOUNDS AS PARENT SUBSTANCES FOR SYNTHESIS OF THROMBIN INHIBITOR

摘要

FIELD: organic chemistry, derivatives of peptides. SUBSTANCE: invention relates to peptide derivative of the general formula (I): A¹-A²-NH-(CH)_n-D where A¹ is a structural fragment of the formulas (IIa) , (IIb) , (IIc) , (IId) and (IIe) ; k = 0-3; m = 1, 2; q = 0, 1, 2 or 3; R¹ - H, C_1-4-alkyl, R¹¹-OOC-alkyl (other values see p. 1 of the invention claim). Compounds of the formula (I) are effective inhibitors of serine proteases, especially thrombin and kininogenases, for example, kallikrein. EFFECT: improved method of synthesis, enhanced effectiveness of compounds as inhibitors of enzymes. 38 cl, 2 tbl, 91 ex