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Modelling binding between CCR5 and CXCR4 receptors and their ligands suggests the surface electrostatic potential of the co-receptor to be a key player in the HIV-1 tropism

机译:对CCR5和CXCR4受体及其配体之间的结合进行建模表明该共受体的表面静电势是HIV-1向性的关键参与者

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摘要

BackgroundCCR5 and CXCR4 are the two membrane-standing proteins that, along with CD4, facilitate entry of HIV particles into the host cell. HIV strains differ in their ability to utilize either CCR5 or CXCR4, and this specificity, also known as viral tropism, is largely determined by the sequence of the V3 loop of the viral envelope protein gp120.
机译:背景CCR5和CXCR4是与CD4一起促进HIV颗粒进入宿主细胞的两种膜蛋白。 HIV菌株利用CCR5或CXCR4的能力各不相同,这种特异性(也称为病毒嗜性)很大程度上取决于病毒包膜蛋白gp120的V3环的序列。

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