Analysis of Sustained Release Behavior of Drug-Containing Tablet Prepared by CO2-Assisted Polymer Compression

摘要

A controlled-release system for drug delivery allows the continuous supply of a drug to the target region at a predetermined rate for a specified period of time. Herein, the sustained release behavior of a drug-containing tablet fabricated through CO2-assisted polymer compression (CAPC) was investigated. CAPC involves placing the drug in the center of a nonwoven fabric, sandwiching this fabric between an integer number of nonwoven fabrics, and applying pressure bonding. An elution test, in which the drug-carrying tablet was immersed in water, showed that sustained-release performance can be controlled by the number of nonwoven fabrics covering the top and bottom of the drug-loaded fabric and compression conditions. A model of sustained drug release was formulated to estimate the effective diffusion coefficient in the porous material. Comparative analysis of the bulk diffusion coefficient revealed that the change in diffusion volume due to change in porosity predominates. The tortuosity of the diffusion path was 3–4, and tended to remain almost constant or increase only slightly when the compression rate was increased. These findings show that sustained drug release can be controlled by incorporating the drug into a nonwoven fabric and using the same raw material to encapsulate it.