Résultats du remplacement valvulaire chez les patients porteurs de rétrécissement valvulaire aortique avec dysfonction ventriculaire gauche sévère

摘要

The operative risk of aortic valve replacement (AVR) due to tight aortic stenosis (AS) associated with severe left ventricular dysfunction is high. Several risk factors for postoperative mortality have been described, but most of the reported case series are heterogeneous. This study aimed to analyze the postoperative results of AVR in patients with isolated tight AS associated with severe left ventricular dysfunction and to identify predictive factors of in-hospital mortality. We conducted a retrospective study of 46 patients with tight AS associated with severe left ventricular dysfunction who had undergone AVR. The average age was 59±12.70 years. 69.6% of patients were in NYHA Class III or IV. Mean EF was 32.3 ± 5.3%, and mean EuroScore was 12.20 ± 8.70. In-hospital mortality accounted for 15.20%. Morbidity was mainly marked by low cardiac output in 35% of cases. Multivariate logistic regression analysis showed that renal insufficiency (OR= 11.94, CI [2.65-72.22], p= 0.03) and congestive cardiac failure (OR= 25.33, CI [3.43-194.74], p= 0.009) were related to the risk of in-hospital mortality. Thirty-nine surviving patients were followed up for an average of 59.6± 21 months. Late mortality accounted for 5%. The functional status had significantly improved. EF increased, on average, by 5.5 units in early postoperative period and by 18 units in late postoperative period. In the long term, end-diastolic and end-systolic diameters were reduced by an average of 8 and 9 mm, respectively. The results of AVR due to tight AS associated with severe left ventricular dysfunction are satisfactory. Congestive heart failure and preoperative renal failure are the main risk factors for in-hospital mortality. Patient’s outcome is marked by reduction in end-diastolic and end-systolic diameters of the left ventricle with improvement of the EF and of their functional status.