OUTIL D'IMAGERIE BASÉE SUR LA RADIOMIQUE POUR SURVEILLER L'INFILTRATION ET DE LYMPHOCYTES TUMORAUX ET LE RÉSULTAT CHEZ DES PATIENTS CANCÉREUX TRAITÉS PAR AGENTS ANTI-PD-1/PD-L1

摘要

The present invention proposes a radiomics-based biomarker for detecting the presence and the density of tumor infiltrating CD8 T-cells in a solid tumor without having to use any biopsy of said tumor. The invention also proposes to use this information to assess the immune phenotype of said solid tumor. In a particular embodiment, the invention proposes to prognose the survival and / or the treatment efficiency of cancer patients treated with immunotherapy such as anti-PD-1/PD- L1 monotherapy.