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Circulating tumor cells tumor-derived extracellular vesicles and plasma cytokeratins in castration-resistant prostate cancer patients

机译：去势抵抗性前列腺癌患者的循环肿瘤细胞肿瘤来源的细胞外囊泡和血浆细胞角蛋白

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摘要

PurposeThe presence of Circulating Tumor Cells (CTCs) in Castration-Resistant Prostate Cancer (CRPC) patients is associated with poor prognosis. In this study, we evaluated the association of clinical outcome in 129 CRPC patients with CTCs, tumor-derived Extracellular Vesicles (tdEVs) and plasma levels of total (CK18) and caspase-cleaved cytokeratin 18 (ccCK18).

机译：目的在去势抵抗性前列腺癌（CRPC）患者中存在循环肿瘤细胞（CTC）与预后不良有关。在这项研究中，我们评估了129例CRPC患者与CTC，肿瘤源性细胞外囊泡（tdEVs）和血浆总水平（CK18）和半胱天冬酶裂解的细胞角蛋白18（ccCK18）的临床结局。

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期刊名称 Oncotarget
作者
Afroditi Nanou; Frank A.W. Coumans; Guus van Dalum; Leonie L. Zeune; David Dolling; Wendy Onstenk; Mateus Crespo; Mariane Sousa Fontes; Pasquale Rescigno; Gemma Fowler; Penny Flohr; Christoph Brune; Stefan Sleijfer; Johann S. de Bono; Leon W.M.M. Terstappen;
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作者单位

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年(卷),期 2018(9),27
年度 2018
页码 19283–19293
总页数 11
原文格式 PDF
正文语种
中图分类肿瘤学;细胞生物学;
关键词
circulating tumor cells (CTCs) tumor-derived Extracellular Vesicles (tdEVs) cytokeratin 18 (CK18) caspase-cleaved cytokeratin 18 (ccCK18) castration-resistant prostate cancer (CRPC);

机译：循环肿瘤细胞（CTC）;肿瘤来源的细胞外囊泡（tdEV）;细胞角蛋白18（CK18）;胱天蛋白酶裂解的细胞角蛋白18（ccCK18）;去势抵抗性前列腺癌（CRPC）;

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专利

1. HER2 expression on tumor-derived extracellular vesicles and circulating tumor cells in metastatic breast cancer [J] . Afroditi Nanou, Leonie Laura Zeune, Francois-Clement Bidard, Breast Cancer Research . 2020,第1期

机译：肿瘤衍生的细胞外囊泡的HER2表达和转移性乳腺癌中的循环肿瘤细胞
2. Detection of tumor-derived extracellular vesicles in plasma from patients with solid cancer [J] . Vitale Silvia R., Helmijr Jean A., Gerritsen Marjolein, BMC Cancer . 2021,第1期

机译：从固体癌患者的血浆中肿瘤衍生细胞外囊泡的检测
3. Detection of circulating miRNAs: comparative analysis of extracellular vesicle-incorporated miRNAs and cell-free miRNAs in whole plasma of prostate cancer patients [J] . Edgars Endzeli??, Andreas Berger, Vita Melne, BMC Cancer . 2017,第1期

机译：循环miRNA的检测：前列腺癌患者全血浆中细胞外囊泡结合的miRNA和无细胞miRNA的比较分析
4. Identification of Circulating Pluripotent Cancer Stem Cells in the Blood of Prostate Cancer Patients for the Diagnosis of Metastatic Cancer [C] . Anette Claudia Schafer, Yawen Ju, Youngbin Tak, International Molecular Medicine Tri-Conference. . 2016

机译：鉴定前列腺癌患者血液中循环多能癌症干细胞诊断转移性癌症
5. Mechanism of Extracellular Matrix Induced Tumor Survival and Drug Resistance in Castration-Resistant Prostate Cancer [D] . Chaudhary, Pooja. 2019

机译：细胞外基质诱导肿瘤存活和抗阉割前列腺癌的耐药机制
6. HER2 expression on tumor-derived extracellular vesicles and circulating tumor cells in metastatic breast cancer [O] . Afroditi Nanou, Leonie Laura Zeune, Francois-Clement Bidard, 2020

机译：肿瘤衍生的细胞外囊泡的HER2表达和转移性乳腺癌中的循环肿瘤细胞
7. Circulating tumor cells, tumor-derived extracellular vesicles and plasma cytokeratins in castration-resistant prostate cancer patients [O] . Afroditi Nanou, Frank A.W. Coumans, Guus van Dalum, 2018

机译：循环肿瘤细胞，肿瘤衍生的细胞外囊泡和血浆细胞角蛋白在抗阉割前列腺癌患者中

Circulating tumor cells tumor-derived extracellular vesicles and plasma cytokeratins in castration-resistant prostate cancer patients

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