Tumor necrosis factor-α −308 G/A polymorphism and risk of sepsis septic shock and mortality: an updated meta-analysis

摘要

BackgroundThe -308G/A polymorphism in the gene encoding tumor necrosis factor-α (TNF-α) has been implicated in sepsis risk in many studies but with variable results. This study aimed to comprehensively assess the evidence of association between this polymorphism and risk of sepsis and sepsis-related mortality.