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Inhibition of TGF-β by a novel PPAR-γ agonist chrysin salvages β-receptor stimulated myocardial injury in rats through MAPKs-dependent mechanism

机译：新型PPAR-γ激动剂chrysin抑制TGF-β通过MAPKs依赖性机制挽救β受体刺激的大鼠心肌损伤

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BackgroundPharmacological stimulation of peroxisome proliferator-activated receptor-gamma (PPAR-γ) has been recognized as a molecular switch in alleviating myocardial injury through modulating oxidative, inflammatory and apoptotic signaling pathways. This study was designed to elucidate the effect of chrysin, a novel PPAR-γ agonist and its functional interaction with TGF-β/MAPKs in isoproterenol-challenged myocardial injury in rats.

机译：背景过氧化物酶体增殖物激活受体-γ（PPAR-γ）的药理刺激已被认为是通过调节氧化，炎症和凋亡信号通路减轻心肌损伤的分子开关。这项研究旨在阐明新的PPAR-γ激动剂chrysin的作用及其与TGF-β/ MAPKs在异丙肾上腺素激发的心肌损伤中的功能相互作用。

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期刊名称 Nutrition Metabolism
作者
Neha Rani; Saurabh Bharti; Jagriti Bhatia; Ameesha Tomar; T C Nag; Ruma Ray; Dharamvir Singh Arya;
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作者单位

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年(卷),期 2015(12),-1
年度 2015
页码 11
总页数 11
原文格式 PDF
正文语种
中图分类营养学;
关键词
Chrysin Isoproterenol Myocardial injury PPAR-γ TGF-β MAPKs;

机译：胰蛋白酶;异丙肾上腺素;心肌损伤;PPAR-γ;TGF-β;MAPKs;
入库时间 2022-08-17 12:27:39

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专利

1. Inhibition of TGF-β by a novel PPAR-γ agonist, chrysin, salvages β-receptor stimulated myocardial injury in rats through MAPKs-dependent mechanism [J] . Neha Rani, Saurabh Bharti, Jagriti Bhatia, Nutrition Metabolism . 2015,第1期

机译：新型PPAR-γ激动剂chrysin抑制TGF-β通过MAPKs依赖性机制挽救β受体刺激的大鼠心肌损伤
2. Chrysin, a PPAR-gamma agonist improves myocardial injury in diabetic rats through inhibiting AGE-RAGE mediated oxidative stress and inflammation [J] . Rani Neha, Bharti Saurabh, Bhatia Jagriti, Chemico-biological interactions . 2016,第Null期

机译：Chrysin，一种PPAR-γ激动剂，可通过抑制AGE-RAGE介导的氧化应激和炎症来改善糖尿病大鼠的心肌损伤
3. Chrysin, a PPAR-gamma agonist improves myocardial injury in diabetic rats through inhibiting AGE-RAGE mediated oxidative stress and inflammation [J] . Rani Neha, Bharti Saurabh, Bhatia Jagriti, Chemico-biological interactions . 2016,第Null期

机译：Chrysin，PPAR-γ激动剂通过抑制年龄α介导的氧化应激和炎症来改善糖尿病大鼠心肌损伤
4. GnRH Receptor Expression and Endometrial Cell Proliferation of Macaca nemestrina after Administration of GnRH Agonist in Controlled Ovarian Stimulation Procedures [C] . Andhea Pradhita, Nurhuda Sahar, Muharram Natadisastra, International Symposium of Biomedical Engineering . 2019

机译：在受控卵巢刺激手术中施用GNRH激动剂后Macaca Nemestrina的GnRH受体表达和子宫内膜细胞增殖
5. Non-opioid mechanisms of kappa agonists: Inhibition of stimulated phosphoinositide hydrolysis. [D] . Duan, Naili. 1996

机译：κ激动剂的非阿片类药物机制：抑制刺激的磷酸肌醇水解。
6. Transforming growth factor-β (TGF-β) activates cytosolic phospholipase A2α (cPLA2α)-mediated prostaglandin E2 (PGE)2/EP1 and peroxisome proliferator-activated-γ (PPAR-γ)/Smad signaling pathways in human liver cancer cells. A NOVEL MECHANISM FOR SUBVERSION OF TGF-β-INDUCED MITOINHIBITION. [O] . Chang Han, A. Jake Demetris, Youhua Liu, 2015

机译：转化生长因子-β（TGF-β）激活人肝癌细胞中胞质磷脂酶A2α（cPLA2α）介导的前列腺素E2（PGE）2 / EP1和过氧化物酶体增殖物激活的γ（PPAR-γ）/ Smad信号通路。转化TGF-β诱导的丝裂抑制的新机制。
7. Inhibition of TGF-β by a novel PPAR-γ agonist, chrysin, salvages β-receptor stimulated myocardial injury in rats through MAPKs-dependent mechanism [O] . Neha Rani, Saurabh Bharti, Jagriti Bhatia, 2015

机译：新型PPAR-γ激动剂chrysin抑制TGF-β通过MAPKs依赖性机制挽救β受体刺激的大鼠心肌损伤

Inhibition of TGF-β by a novel PPAR-γ agonist chrysin salvages β-receptor stimulated myocardial injury in rats through MAPKs-dependent mechanism

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