Noninvasive Evaluation of Left Ventricular Diastolic Function in Patients with Angina Pectoris

摘要

To assess the disturbed left ventricular diastolic filling by pulsed Doppler echocardiography in patients with angina pectoris who have normal systolic function, 55 subjects (33 angina patients with, 22 control subjects without significant (⩾75%) coronary artery narrowing) underwent pulsed Doppler echocardiography examination one day before coronary arteriography.From analysis of the transmitral flow velocity curve, diastolic time intervals, peak early and late atrial flow velocities, the ratio of early to atrial peak flow velocity, and deceleration slope after peak early flow velocity were measured. The angina group had a significantly higher peak atrial flow velocity (50.1 ± 10.0 cm/sec vs. 43.7 ± 9.0, p<0.05) and a lower ratio of early to atrial peak flow velocity (0.91 ± 0.24 vs. 1.17 ± 0.30, p<0.005), but peak early flow velocity, deceleration slope, and diastolic time intervals were similar in both groups. Therefore, the pulsed Doppler technique using the transmitral flow velocity curve is thought to be useful in the noninvasive evaluation of diastolic function even in patients with angina pectoris who have normal systolic function and no left ventricular hypertrophy.