Effect modification of air pollution on Urinary 8-Hydroxy-2-Deoxyguanosine by genotypes: an application of the multiple testing procedure to identify significant SNP interactions

摘要

BackgroundAir pollution is associated with adverse human health, but mechanisms through which pollution exerts effects remain to be clarified. One suggested pathway is that pollution causes oxidative stress. If so, oxidative stress-related genotypes may modify the oxidative response defenses to pollution exposure.