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Attitudes of pregnant women and male partners towards non-invasive prenatal testing and widening the scope of prenatal screening

机译:孕妇和男性伴侣对无创产前检查和扩大产前检查范围的态度

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摘要

Non-invasive prenatal testing (NIPT) and its potential to test for multiple disorders has received much attention. This study explores attitudes of women and men towards NIPT, and their views on widening the scope of prenatal testing in a country with a low uptake of prenatal screening (The Netherlands). Five focus groups with low-risk pregnant women (n=28), three focus groups with men (n=19) and 13 interviews with high- and low-risk pregnant women were conducted. Participants felt that current prenatal screening has great disadvantages such as uncertain results and risk of miscarriage from follow-up diagnostics. Characteristics of NIPT (accurate, safe and early testing) could therefore diminish these disadvantages of prenatal screening and help lower the barrier for participation. This suggests that NIPT might allow couples to decide about prenatal testing based mostly on their will to test or not, rather than largely based on fear of miscarriage risk or the uncertainty of results. The lower barrier for participation was also seen as a downside that could lead to uncritical use or pressure to test. Widening the scope of prenatal testing was seen as beneficial for severe disorders, although it was perceived difficult to determine where to draw the line. Participants argued that there should be a limit to the scope of NIPT, avoiding testing for minor abnormalities. The findings suggest that NIPT could enable more meaningful decision-making for prenatal screening. However, to ensure voluntary participation, especially when testing for multiple disorders, safeguards on the basis of informed decision-making will be of utmost importance.
机译:非侵入性产前检查(NIPT)及其测试多种疾病的潜力已受到广泛关注。这项研究探讨了男女对NIPT的态度,以及他们在扩大产前筛查吸收率低的国家(荷兰)中扩大产前检测范围的观点。进行了五个低风险孕妇专题小组(n = 28),三个男性重点小组(n = 19)以及对高危和低危孕妇的13次访谈。与会人员认为,当前的产前检查存在很大的弊端,例如不确定的结果和后续诊断导致流产的风险。因此,NIPT的特征(准确,安全和早期测试)可以消除产前筛查的这些缺点,并有助于降低参与障碍。这表明,NIPT可能允许夫妇主要根据他们的测试意愿与否来决定产前检查,而不是主要基于对流产风险或结果不确定性的恐惧。较低的参与障碍也被视为不利因素,可能导致不加批判地使用或施加测试压力。扩大产前检查的范围被认为对严重的疾病有益,尽管人们认为很难确定界限。与会者认为,应限制NIPT的范围,避免对次要异常进行测试。研究结果表明,NIPT可以为产前筛查提供更有意义的决策。但是,为了确保自愿参与,特别是在测试多种疾病时,在知情决策的基础上采取的保障措施至关重要。

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