METHOD FOR DETECTING CHROMOSOMAL ABNORMALITIES IN LOW-RISK PREGNANT WOMEN BASED ON THE RESULTS OF COMBINED PRENATAL SCREENING IN THE SECOND AND THIRD TRIMESTER OF PREGNANCY

摘要

FIELD: medicine.;SUBSTANCE: invention relates to the field of medicine, namely to ultrasound diagnostics. A method for detecting chromosomal abnormalities in low-risk pregnant women based on the results of combined prenatal screening in the second and third trimester of pregnancy is described. The method includes conducting combined prenatal screening at 11-14 weeks of gestation and classification into risk groups for chromosomal abnormalities. From the low-risk group, a group of medium-risk pregnant women is distinguished, in whom the risk of developing chromosomal abnormalities is in the range of 1: 100-1: 987, in this group they conduct an audit of the combined screening protocols, an assessment of the archive of saved images and biochemical markers, 4 markers are analyzed: β-HCG>1.7 (MoM); PAPP-A ≤ 0.59 (MoM); β-hCG/PAPP-A> 2; β-hCG and PAPP-A < 0.5 (МОМ), and if none of these markers are present and all ultrasound diagnostic criteria are met, then the risk is considered low, routing in such cases corresponds to the low-risk group.;EFFECT: invention expands the arsenal of methods for detecting chromosomal abnormalities in pregnant fetuses.;1 cl, 12 dwg, 1 tbl, 3 ex