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Possible ameliorative effects of antioxidants on propionic acid / clindamycin - induced neurotoxicity in Syrian hamsters

机译：抗氧化剂可能对改善丙酸/克林霉素诱导的叙利亚仓鼠神经毒性的改善作用

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BackgroundPropionic acid (PA) found in some foods and formed as a metabolic product of gut bacteria has been reported to mimic/mediate the effects of autism. The present study was undertaken to compare the effect of orally administered PA with that of clindamycin-induced PA-microbial producers in inducing persistent biochemical autistic features in hamsters. The neuroprotective potency of carnosine and carnitine supplements against PA toxicity was also investigated.

机译：背景技术据报道，在某些食品中发现的丙酸（PA）可以作为肠道细菌的代谢产物而形成，可以模仿/介导自闭症的影响。进行本研究以比较口服施用的PA和克林霉素诱导的PA微生物生产商在诱导仓鼠持久性生化自闭症方面的作用。还研究了肌肽和肉碱补充剂对PA毒性的神经保护作用。

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期刊名称 Gut Pathogens
作者
Afaf El-Ansary; Ghada Shaker; Nikhat J Siddiqi; Laila Y Al-Ayadhi;
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作者单位

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年(卷),期 2013(5),-1
年度 2013
页码 32
总页数 6
原文格式 PDF
正文语种
中图分类微生物学;肠道病毒与肝炎病毒;肝及胆疾病;肠疾病;
关键词
Autism Clindamycin Propionic acid Carnosine Carnitine Cortex Medulla;

机译：自闭症;克林霉素;丙酸;肌肽;肉碱;皮质;延髓;
入库时间 2022-08-17 12:08:50

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专利

1. Possible ameliorative effects of antioxidants on propionic acid / clindamycin - induced neurotoxicity in Syrian hamsters [J] . Afaf El-Ansary, Ghada Shaker, Nikhat J Siddiqi, Gut Pathogens . 2013,第2009期

机译：抗氧化剂对丙酸/克林霉素诱导的叙利亚仓鼠神经毒性的可能改善作用
2. Therapeutic effects of probiotics on neurotoxicity induced by clindamycin and propionic acid in juvenile hamsters (vol 33, pg 1811, 2018) [J] . Al-Orf Nora, El-Ansary Afaf, Bjorklund Geir, Metabolic brain disease . 2018,第6期

机译：益生菌对少年霉素和丙酸丙酸诱导神经毒性的治疗作用（Vol 33，PG 1811,2018）
3. Therapeutic effects of probiotics on neurotoxicity induced by clindamycin and propionic acid in juvenile hamsters [J] . Al-Orf Nora, El-Ansary Afaf, Bjorklund Geir, Metabolic brain disease . 2018,第6期

机译：益生菌对少年霉素诱导神经霉素诱导的神经毒性的治疗作用
4. Role of A-lipoid acid (ALA) in ameliorating arsenic induced developmental neurotoxicity (rat hippocampus) [C] . S. Dixit, P. Dhar, R.D. Mehra International Congress: Arsenic in the Environment . 2010

机译：A-脂醇（ALA）在改善砷诱导发育神经毒性（大鼠海马）中的作用
5. Mechanisms for the differential effects of dietary fatty acids and cholesterol on high density lipoprotein (HDL) and non-high density lipoprotein (NHDL) metabolism in the Golden-Syrian hamster [D] . Dorfman, Suzanne Erin 2005

机译：饮食脂肪酸和胆固醇对金叙利亚仓鼠高密度脂蛋白（HDL）和非高密度脂蛋白（NHDL）代谢差异影响的机制
6. The neurotoxic effect of clindamycin - induced gut bacterial imbalance and orally administered propionic acid on DNA damage assessed by the comet assay: protective potency of carnosine and carnitine [O] . Afaf El-Ansary, Ghada H Shaker, Amina R El-Gezeery, 2013

机译：通过彗星试验评估了克林霉素诱导的肠道细菌失衡和口服丙酸对DNA损伤的神经毒性作用：肌肽和肉碱的保护作用
7. Possible ameliorative effects of antioxidants on propionic acid / clindamycin - induced neurotoxicity in Syrian hamsters [O] . Afaf El-Ansary, Ghada Shaker, Nikhat J Siddiqi, 2013

机译：抗氧化剂可能对改善丙酸/克林霉素诱导的叙利亚仓鼠神经毒性的改善作用
8. Alterations in the Metabolism of Benzo(A)Pyrene in Syrian Hamster Embryo (SHE) Cells Pretreated with Phenolic Antioxidants [R] . Strniste, G. F., Okinaka, R. T., Chen, D. J. 1983

机译：用酚类抗氧化剂预处理的叙利亚仓鼠胚胎（sHE）细胞中苯并（a）芘代谢的变化

Possible ameliorative effects of antioxidants on propionic acid / clindamycin - induced neurotoxicity in Syrian hamsters

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