Biomimetic mineralisation is an alternative restorative methodology that imitates the natural process of mineralisation. We aimed to systematically review the laboratory methods on the biomimetic mineralisation of demineralised enamel. A search in the PubMed, ScienceDirect, and ISI Web of Science databases was performed. Clinical trials, reviews, non-English articles, animal teeth, non-tooth substrates, and irrelevant studies were excluded. After screening the titles and abstracts of initially searched articles, 20 papers remained for full-text analysis. Eight articles were identified from the references of the remaining papers. A total of 28 studies were included in this systematic review. We found that protein or protein analogues were used to mimic the function of natural protein in 23 studies. Bioactive components inspired by mussel, an agarose hydrogel model, a glycerine-enriched gelatine technique, and ethylenediaminetetraacetic acid, were also used for biomimetic mineralisation of enamel. These laboratory studies reported success in the biomimetic mineralisation of enamel. Potential further research on the biomimetic mineralisation of enamel was discussed.
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机译：仿生矿化是模仿矿化自然过程的替代性恢复方法。我们旨在系统地审查脱矿质搪瓷仿生矿化的实验室方法。在PubMed，ScienceDirect和ISI Web of Science数据库中进行了搜索。临床试验，评论，非英文文章，动物牙齿，非牙齿基质和无关的研究均被排除在外。在筛选了最初搜索的文章的标题和摘要之后，剩下20篇论文需要全文分析。从其余论文的参考文献中确定了八篇文章。该系统评价共纳入28项研究。我们在23项研究中发现蛋白质或蛋白质类似物被用来模仿天然蛋白质的功能。受贻贝启发的生物活性成分，琼脂糖水凝胶模型，富含甘油的明胶技术和乙二胺四乙酸也用于仿生搪瓷。这些实验室研究报告了搪瓷仿生矿化的成功。讨论了对搪瓷仿生矿化的潜在进一步研究。
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