Genetic dissection of the polyoxin building block-carbamoylpolyoxamic acid biosynthesis revealing the pathway redundancy in metabolic networks

摘要

BackgroundPolyoxin, a peptidyl nucleoside antibiotic, consists of three building blocks including a nucleoside skeleton, polyoximic acid (POIA), and carbamoylpolyoxamic acid (CPOAA), however, little is known about the “pathway redundancy” of the metabolic networks directing the CPOAA biosynthesis in the cell factories of the polyoxin producer.