Peroral administration of viable Pseudomonas aeruginosa into the stomach of mice resulted in an acute systemic infection, with death occurring within 72 h. One strain, ATCC 19660, a non-encapsulated form of P. aeruginosa, had a median lethal dose of 5.3 X 10(6) colony-forming units, whereas two encapsulated strains, ATCC 17933 and 17934, had median lethal dose values of 5.0 x 10(7) and 5.6 x 10(7) colony-forming units, respectively. Each strain required fewer organisms to establish a lethal infection via the stomach than by intravenous or intraperitoneal routes. The non-encapsulated strain, ATCC 19660, did not cause any diarrhea in the infected animals, whereas the two encapsulated strains, although less virulent, caused diarrhea when administered perorally. No signs of necrosis were noted within the gastrointestinal tract; however, hematogenous spread of the organism resulted in a vasculitis associated with the pulmonary vessels and bacterial invasion of the renal tissues. Treatment of animals with antineoplastic drugs 24 h before or simultaneously with peroral challenge resulted in an increased susceptibility to infection.
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机译：对小鼠的胃内经口施用活的铜绿假单胞菌导致急性全身感染，死亡发生在72小时内。一种菌株，ATCC 19660，一种非封装形式的铜绿假单胞菌，具有5.3 X 10（6）集落形成单位的中值致死剂量，而两种封装的菌株ATCC 17933和17934的中值致死剂量值为5.0。 x 10（7）和5.6 x 10（7）菌落形成单位。与通过静脉内或腹膜内途径相比，每种菌株需要更少的生物体通过胃建立致命感染。未封装的菌株ATCC 19660在感染的动物中不会引起任何腹泻，而两种封装的菌株虽然毒性较小，但经口给药时会引起腹泻。胃肠道内未见坏死迹象。然而，该生物的血源性扩散导致与肺血管和细菌侵入肾组织有关的血管炎。在经口攻击之前或与之同时进行抗肿瘤药治疗的动物24小时，导致感染的敏感性增加。
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