As part of a community screening study to assess the long-term health outcomes among residents of Walkerton, Ontario, after contamination of its municipal water supply by Escherichia coli O157:H7 and Campylobacter in 2000, we identified 100 adults who had proteinuria and polyuria but no medical history or medication use to explain their condition. Fifty-six of the 100 participants underwent both initial and confirmatory urine concentration tests, which showed that their urine osmolality could reach normal levels. We then instructed them to reduce their fluid intake to less than 2 L/d for 1 week. The proteinuria and polyuria were largely reversed by this manoeuvre. We do not know at this time whether the proteinuria associated with excessive fluid intake in these otherwise healthy people will affect their kidney function in the long term.
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机译:作为评估2000年大肠杆菌O157:H7和弯曲杆菌污染其市政供水后,安大略省沃克顿居民长期健康结果的社区筛查研究的一部分,我们确定了100名患有蛋白尿和多尿症的成年人,没有病史或用药来解释他们的病情。在100名参与者中,有56名接受了初始和确定性尿液浓度测试,这表明他们的尿渗透压可以达到正常水平。然后,我们指示他们在1周内将其液体摄入量减少到2 L / d以下。蛋白尿和多尿症被这种动作很大程度上逆转了。目前我们还不知道这些原本健康的人中与过量饮水有关的蛋白尿症是否会长期影响其肾功能。
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