Allowing for non-adherence to treatment in a randomized controlled trial oftwo antidepressants (citalopram versus reboxetine): an example from theGENPOD trial

摘要

BackgroundMeta-analyses suggest that reboxetine may be less effective than other antidepressants. Such comparisons may be biased by lower adherence to reboxetine and subsequent handling of missing outcome data. This study illustrates how to adjust for differential non-adherence and hence derive an unbiased estimate of the efficacy of reboxetine compared with citalopram in primary care patients with depression.